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Understanding Anti-Obesity Medications

Dr. Bilkisu Gaye

A New Approach to Weight Management


Introduction: The Weight Loss Dilemma


For many people, losing weight can feel like an uphill battle. While diet and exercise are key components of a healthy lifestyle, they may not always be enough for significant weight loss. That’s where Anti-Obesity Medications (AOMs) come into play. These medications can provide the extra boost needed to help individuals reach their health goals.


We recently hosted a successful lunch and learn on this very topic, and the interest was tremendous! So, we’re sharing this blog to recap the key points for those who couldn’t attend or want a refresher.



The Importance of Weight Loss: More Than Just a Number


Did you know that losing just 5% of your body weight can have significant health benefits? While it might not sound like much, this level of weight loss can:


  • Lower your blood pressure and cholesterol levels.
  • Improve your blood sugar control, reducing the risk of type 2 diabetes.
  • Reduce stress on your joints, making movement easier and less painful.


In fact, studies have shown that losing just 5-10% of your body weight can lead to meaningful improvements in your overall health.



What Are Anti-Obesity Medications (AOMs)?


Anti-Obesity Medications are FDA-approved drugs designed to help people manage their weight effectively. They are typically used in combination with lifestyle changes, such as a healthy diet and regular exercise. Here’s a look at some of the common AOMs available today:


Semaglutide (Wegovy®)

  • How it works: Semaglutide mimics a hormone that helps regulate appetite, making you feel full faster and longer.
  • How it’s taken: It’s a weekly injection, which may sound intimidating, but many patients find it manageable with practice.
  • Side effects: Common issues include nausea, diarrhea, and constipation. Eating smaller meals and staying hydrated can help reduce these symptoms.
  • Important note: It has a black box warning for the risk of thyroid tumors, so it’s not recommended for those with a family history of thyroid cancer.


Orlistat (Xenical, Alli®)

  • How it works: Orlistat blocks about 30% of the fat you eat from being absorbed, which helps reduce your overall calorie intake.
  • How it’s taken: It’s a pill you take with meals that contain fat. You’ll also need a multivitamin since it can interfere with vitamin absorption.
  • Side effects: Oily stools and digestive discomfort can occur, especially if you eat high-fat foods.


Phentermine/Topiramate ER (Qsymia®)

  • How it works: This combination medication reduces appetite and increases feelings of fullness.
  • How it’s taken: It’s a daily tablet, with doses gradually increased over time.
  • Side effects: Common side effects include insomnia and dry mouth, so it’s best taken in the morning.


Naltrexone/Bupropion ER (Contrave®)

  • How it works: It targets brain pathways that influence hunger and cravings.
  • How it’s taken: The dosage is gradually increased over several weeks.
  • Side effects: Nausea and headaches are common, and it’s important to monitor blood pressure regularly.


Liraglutide (Saxenda®)

  • How it works: Similar to Semaglutide, it helps control appetite and delays stomach emptying.
  • How it’s taken: It’s a daily injection, with doses increased gradually to minimize side effects.
  • Side effects: Nausea and injection site reactions are common. Rotating injection sites can help reduce irritation.


Tirzepatide (Zepbound™)

  • How it works: This medication targets two gut hormones to help control appetite and blood sugar. It has shown remarkable results in clinical trials, with many patients achieving significant weight loss. 
  • How it is taken: Weekly injections that can be titrated up just like semaglutide
  • Side effects: Similar to semaglutide but some say with less nausea and vomiting



Who Should Consider Anti-Obesity Medications?


AOMs aren’t for everyone, but they may be a good fit for:


  • Individuals with a BMI of 30 or higher.
  • Those with a BMI of 27 or higher who also have weight-related health issues like type 2 diabetes, high blood pressure, or sleep apnea.


However, these medications are not recommended if you are pregnant, breastfeeding, or have certain medical conditions (such as a history of thyroid cancer). It’s important to consult your healthcare provider to see if AOMs are right for you.



Conclusion: A Comprehensive Approach to Weight Loss


While Anti-Obesity Medications can be an effective part of a weight management plan, they are not a magic solution. The best results come when these medications are combined with healthy eating, regular physical activity, and ongoing support from healthcare professionals.


If you’re considering AOMs as part of your weight loss journey, the team at Designed4Wellness is here to help. Together, we can develop a personalized plan that fits your needs and health goals. Contact us for more details or sign up for our next 10 + 20 Program which starts January 6, 2025



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